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The JE case is suspected as per clinical signs/symptoms and it has to be confirmed in laboratory as follows:-

Clinical: Acute onset of fever <7 days duration associated with  change in mental status (may include irritability, somnolence or abnormal behavior greater than that seen with usual febrile illness) and/or new onset of seizures (excluding simple febrile seizures).

Confirmatory test:- It has to be laboratory confirmed with any one of the following markers: 

  • Presence of IgM antibody in serum and/ or CSF to JE Virus
  • Four fold difference in IgG antibody titre in paired sera
  • Virus isolation from brain tissue 
  • Antigen detection by immunofluroscence
  • Nucleic acid detection by PCR