HOW JE IS DIAGNOSED?
BackThe JE case is suspected as per clinical signs/symptoms and it has to be confirmed in laboratory as follows:-
Clinical: Acute onset of fever <7 days duration associated with change in mental status (may include irritability, somnolence or abnormal behavior greater than that seen with usual febrile illness) and/or new onset of seizures (excluding simple febrile seizures).
Confirmatory test:- It has to be laboratory confirmed with any one of the following markers:
- Presence of IgM antibody in serum and/ or CSF to JE Virus
- Four fold difference in IgG antibody titre in paired sera
- Virus isolation from brain tissue
- Antigen detection by immunofluroscence
- Nucleic acid detection by PCR